Parkinson's disease: Evolution of cognitive impairment and CSF Aβ1-42 profiles in a prospective longitudinal study

Research output: Contribution to journalArticle


Objective: To evaluate the evolution of cognitive impairment in relation to cerebrospinal fluid (CSF) profiles of amyloid-β (Aβ), total-Tau and phosphorylated-Tau in Parkinson's disease (PD). Methods: Prospective, longitudinal, observational study up to 10 years with follow-up every 2 years. We assessed CSF profiles in 415 patients with sporadic PD (median age 66; 63% men) and 142 healthy controls (median age 62; 43% men). Results: Patients with PD with low CSF Aβ1-42 levels at baseline were more often cognitively impaired than patients with intermediate and high Aβ1-42 levels. Sixty-seven per cent of the patients with low Aβ1-42 levels at baseline and normal cognition developed cognitive impairment during follow-up, compared with 41% and 37% of patients having intermediate and high CSF Aβ1-42 levels. Kaplan-Meier survival curves and Cox regression revealed that patients with low CSF Aβ1-42 levels at baseline developed cognitive impairment more frequently and earlier during follow-up. Conclusion: We conclude that in patients with sporadic PD, low levels of Aβ1-42 are associated with a higher risk of developing cognitive impairment earlier in the disease process at least in a subgroup of patients.


  • Stefanie Lerche
  • Isabel Wurster
  • Benjamin Röben
  • Gerrit Machetanz
  • Milan Zimmermann
  • Felix Bernhard
  • Elke Stransky
  • Christian Deuschle
  • Claudia Schulte
  • Oskar Hansson
  • Henrik Zetterberg
  • Thomas Gasser
  • Daniela Berg
  • Walter Maetzler
  • Kathrin Brockmann
External organisations
  • University of Tübingen
  • Skåne University Hospital
  • Sahlgrenska University Hospital
  • University College London
  • University of Gothenburg
  • University of Kiel
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences


  • amyloid-beta, CSF, longitudinal, Parkinson
Original languageEnglish
Pages (from-to)165-170
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number2
Early online date2018 Sep 25
Publication statusPublished - 2019
Publication categoryResearch