Parkinsons sjukdom – heterogen och komplex i sitt kliniska uttryck - Individuella kombinationer av symtom som ändrar sig över tid kräver behandlingsjusteringar och anpassningar

Research output: Contribution to journalArticle

Abstract

Parkinson's disease is the second most common neurodegenerative disease. Lewy bodies with alpha-synuclein as the major component and loss of dopaminergic nerve cells in substantia nigra are neuropathological features. The diagnosis of Parkinson's disease is based on the occurrence of bradykinesia, rigidity and resting tremor. The disease is also associated with several non-motor symptoms. The therapy is mainly based on pharmacological treatment to increase dopamine signaling and neurosurgical deep brain stimulation. The symptoms and signs of the progressive disease change over time, requiring treatment adjustments. Patients should be followed by a physician, nurse and a multidisciplinary team with expertise in Parkinson's disease.

Details

Authors
Organisations
External organisations
  • Karolinska University Hospital
  • Linköping University
  • Uppsala University Hospital
  • Sahlgrenska University Hospital
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Translated title of the contributionParkinson's disease - heterogeneous and complex in its clinical presentation
Original languageSwedish
Article numberFWED
JournalLäkartidningen
Volume117
Publication statusPublished - 2020 Mar 9
Publication categoryResearch
Peer-reviewedYes