Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

Research output: Contribution to journalReview article

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Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. / Bastide, Matthieu F; Meissner, Wassilios G; Picconi, Barbara; Fasano, Stefania; Fernagut, Pierre-Olivier; Feyder, Michael; Francardo, Veronica; Alcacer, Cristina; Ding, Yunmin; Brambilla, Riccardo; Fisone, Gilberto; Jon Stoessl, A; Bourdenx, Mathieu; Engeln, Michel; Navailles, Sylvia; De Deurwaerdère, Philippe; Ko, Wai Kin D; Simola, Nicola; Morelli, Micaela; Groc, Laurent; Rodriguez, Maria-Cruz; Gurevich, Eugenia V; Quik, Maryka; Morari, Michele; Mellone, Manuela; Gardoni, Fabrizio; Tronci, Elisabetta; Guehl, Dominique; Tison, François; Crossman, Alan R; Kang, Un Jung; Steece-Collier, Kathy; Fox, Susan; Carta, Manolo; Cenci Nilsson, Angela; Bézard, Erwan.

In: Progress in Neurobiology, Vol. 132, No. Jul 21, 2015, p. 96-168.

Research output: Contribution to journalReview article

Harvard

Bastide, MF, Meissner, WG, Picconi, B, Fasano, S, Fernagut, P-O, Feyder, M, Francardo, V, Alcacer, C, Ding, Y, Brambilla, R, Fisone, G, Jon Stoessl, A, Bourdenx, M, Engeln, M, Navailles, S, De Deurwaerdère, P, Ko, WKD, Simola, N, Morelli, M, Groc, L, Rodriguez, M-C, Gurevich, EV, Quik, M, Morari, M, Mellone, M, Gardoni, F, Tronci, E, Guehl, D, Tison, F, Crossman, AR, Kang, UJ, Steece-Collier, K, Fox, S, Carta, M, Cenci Nilsson, A & Bézard, E 2015, 'Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.', Progress in Neurobiology, vol. 132, no. Jul 21, pp. 96-168. https://doi.org/10.1016/j.pneurobio.2015.07.002

APA

Bastide, M. F., Meissner, W. G., Picconi, B., Fasano, S., Fernagut, P-O., Feyder, M., ... Bézard, E. (2015). Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. Progress in Neurobiology, 132(Jul 21), 96-168. https://doi.org/10.1016/j.pneurobio.2015.07.002

CBE

Bastide MF, Meissner WG, Picconi B, Fasano S, Fernagut P-O, Feyder M, Francardo V, Alcacer C, Ding Y, Brambilla R, Fisone G, Jon Stoessl A, Bourdenx M, Engeln M, Navailles S, De Deurwaerdère P, Ko WKD, Simola N, Morelli M, Groc L, Rodriguez M-C, Gurevich EV, Quik M, Morari M, Mellone M, Gardoni F, Tronci E, Guehl D, Tison F, Crossman AR, Kang UJ, Steece-Collier K, Fox S, Carta M, Cenci Nilsson A, Bézard E. 2015. Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. Progress in Neurobiology. 132(Jul 21):96-168. https://doi.org/10.1016/j.pneurobio.2015.07.002

MLA

Vancouver

Author

Bastide, Matthieu F ; Meissner, Wassilios G ; Picconi, Barbara ; Fasano, Stefania ; Fernagut, Pierre-Olivier ; Feyder, Michael ; Francardo, Veronica ; Alcacer, Cristina ; Ding, Yunmin ; Brambilla, Riccardo ; Fisone, Gilberto ; Jon Stoessl, A ; Bourdenx, Mathieu ; Engeln, Michel ; Navailles, Sylvia ; De Deurwaerdère, Philippe ; Ko, Wai Kin D ; Simola, Nicola ; Morelli, Micaela ; Groc, Laurent ; Rodriguez, Maria-Cruz ; Gurevich, Eugenia V ; Quik, Maryka ; Morari, Michele ; Mellone, Manuela ; Gardoni, Fabrizio ; Tronci, Elisabetta ; Guehl, Dominique ; Tison, François ; Crossman, Alan R ; Kang, Un Jung ; Steece-Collier, Kathy ; Fox, Susan ; Carta, Manolo ; Cenci Nilsson, Angela ; Bézard, Erwan. / Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. In: Progress in Neurobiology. 2015 ; Vol. 132, No. Jul 21. pp. 96-168.

RIS

TY - JOUR

T1 - Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

AU - Bastide, Matthieu F

AU - Meissner, Wassilios G

AU - Picconi, Barbara

AU - Fasano, Stefania

AU - Fernagut, Pierre-Olivier

AU - Feyder, Michael

AU - Francardo, Veronica

AU - Alcacer, Cristina

AU - Ding, Yunmin

AU - Brambilla, Riccardo

AU - Fisone, Gilberto

AU - Jon Stoessl, A

AU - Bourdenx, Mathieu

AU - Engeln, Michel

AU - Navailles, Sylvia

AU - De Deurwaerdère, Philippe

AU - Ko, Wai Kin D

AU - Simola, Nicola

AU - Morelli, Micaela

AU - Groc, Laurent

AU - Rodriguez, Maria-Cruz

AU - Gurevich, Eugenia V

AU - Quik, Maryka

AU - Morari, Michele

AU - Mellone, Manuela

AU - Gardoni, Fabrizio

AU - Tronci, Elisabetta

AU - Guehl, Dominique

AU - Tison, François

AU - Crossman, Alan R

AU - Kang, Un Jung

AU - Steece-Collier, Kathy

AU - Fox, Susan

AU - Carta, Manolo

AU - Cenci Nilsson, Angela

AU - Bézard, Erwan

PY - 2015

Y1 - 2015

N2 - Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.

AB - Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately experienced by the vast majority of patients. In addition, psychiatric conditions often manifested as compulsive behaviours, are emerging as a serious problem in the management of L-dopa therapy. The present review attempts to provide an overview of our current understanding of dyskinesia and other L-dopa-induced dysfunctions, a field that dramatically evolved in the past twenty years. In view of the extensive literature on LID, there appeared a critical need to re-frame the concepts, to highlight the most suitable models, to review the central nervous system (CNS) circuitry that may be involved, and to propose a pathophysiological framework was timely and necessary. An updated review to clarify our understanding of LID and other L-dopa-related side effects was therefore timely and necessary. This review should help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.

U2 - 10.1016/j.pneurobio.2015.07.002

DO - 10.1016/j.pneurobio.2015.07.002

M3 - Review article

VL - 132

SP - 96

EP - 168

JO - Progress in Neurobiology

T2 - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 1873-5118

IS - Jul 21

ER -