PDGF-B Is Required for Development of the Glymphatic System

Research output: Contribution to journalArticle


title = "PDGF-B Is Required for Development of the Glymphatic System",
abstract = "The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.",
keywords = "aquaporin 4, astrocytes, cerebrospinal fluid, glymphatic system, platelet-derived growth factor B, postnatal development",
author = "Munk, {Anne Sofie} and Wei Wang and B{\`e}chet, {Nicholas Burdon} and Eltanahy, {Ahmed M.} and Cheng, {Anne Xiaoan} and Bj{\"o}rn Sigurdsson and Abdellatif Benraiss and M{\"a}e, {Maarja A.} and Kress, {Benjamin Travis} and Kelley, {Douglas H.} and Christer Betsholtz and Kjeld M{\o}llg{\aa}rd and Anja Meissner and Maiken Nedergaard and Iben Lundgaard",
year = "2019",
doi = "10.1016/j.celrep.2019.02.050",
language = "English",
pages = "2955--2969.e3",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",