PDGF-B Is Required for Development of the Glymphatic System

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PDGF-B Is Required for Development of the Glymphatic System. / Munk, Anne Sofie; Wang, Wei; Bèchet, Nicholas Burdon; Eltanahy, Ahmed M.; Cheng, Anne Xiaoan; Sigurdsson, Björn; Benraiss, Abdellatif; Mäe, Maarja A.; Kress, Benjamin Travis; Kelley, Douglas H.; Betsholtz, Christer; Møllgård, Kjeld; Meissner, Anja; Nedergaard, Maiken; Lundgaard, Iben.

In: Cell Reports, 2019, p. 2955-2969.e3.

Research output: Contribution to journalArticle

Harvard

Munk, AS, Wang, W, Bèchet, NB, Eltanahy, AM, Cheng, AX, Sigurdsson, B, Benraiss, A, Mäe, MA, Kress, BT, Kelley, DH, Betsholtz, C, Møllgård, K, Meissner, A, Nedergaard, M & Lundgaard, I 2019, 'PDGF-B Is Required for Development of the Glymphatic System', Cell Reports, pp. 2955-2969.e3. https://doi.org/10.1016/j.celrep.2019.02.050

APA

CBE

Munk AS, Wang W, Bèchet NB, Eltanahy AM, Cheng AX, Sigurdsson B, Benraiss A, Mäe MA, Kress BT, Kelley DH, Betsholtz C, Møllgård K, Meissner A, Nedergaard M, Lundgaard I. 2019. PDGF-B Is Required for Development of the Glymphatic System. Cell Reports. 2955-2969.e3. https://doi.org/10.1016/j.celrep.2019.02.050

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Author

Munk, Anne Sofie ; Wang, Wei ; Bèchet, Nicholas Burdon ; Eltanahy, Ahmed M. ; Cheng, Anne Xiaoan ; Sigurdsson, Björn ; Benraiss, Abdellatif ; Mäe, Maarja A. ; Kress, Benjamin Travis ; Kelley, Douglas H. ; Betsholtz, Christer ; Møllgård, Kjeld ; Meissner, Anja ; Nedergaard, Maiken ; Lundgaard, Iben. / PDGF-B Is Required for Development of the Glymphatic System. In: Cell Reports. 2019 ; pp. 2955-2969.e3.

RIS

TY - JOUR

T1 - PDGF-B Is Required for Development of the Glymphatic System

AU - Munk, Anne Sofie

AU - Wang, Wei

AU - Bèchet, Nicholas Burdon

AU - Eltanahy, Ahmed M.

AU - Cheng, Anne Xiaoan

AU - Sigurdsson, Björn

AU - Benraiss, Abdellatif

AU - Mäe, Maarja A.

AU - Kress, Benjamin Travis

AU - Kelley, Douglas H.

AU - Betsholtz, Christer

AU - Møllgård, Kjeld

AU - Meissner, Anja

AU - Nedergaard, Maiken

AU - Lundgaard, Iben

PY - 2019

Y1 - 2019

N2 - The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.

AB - The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.

KW - aquaporin 4

KW - astrocytes

KW - cerebrospinal fluid

KW - glymphatic system

KW - platelet-derived growth factor B

KW - postnatal development

U2 - 10.1016/j.celrep.2019.02.050

DO - 10.1016/j.celrep.2019.02.050

M3 - Article

SP - 2955-2969.e3

JO - Cell Reports

T2 - Cell Reports

JF - Cell Reports

SN - 2211-1247

ER -