PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

Research output: Contribution to journalArticle

Abstract

Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

Details

Authors
  • X. Li
  • A. Pontén
  • K. Aase
  • L. Karlsson
  • A. Abramsson
  • M. Uutela
  • G. Bäckström
  • M. Hellström
  • Hans Ehrencrona
  • H. Li
  • P. Soriano
  • C. Betsholtz
  • C. H. Heldin
  • K. Alitalo
  • A. Ostman
  • U. Eriksson
External organisations
  • External Organization - Unknown
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • Platelet-Derived Growth Factor, Myocardium, Molecular Sequence Data, Mice, Mesoderm, Lymphokines, Ligands, Kidney, Insects, In Situ Hybridization, Humans, Developmental, Gene Expression Regulation, Gene Expression, Epithelial Cells, Endopeptidases, Animals, COS Cells, Protein Structure, Tertiary, RNA, Messenger, Rabbits, Receptor, Platelet-Derived Growth Factor alpha, Sequence Homology, Amino Acid, Transgenes
Original languageEnglish
Pages (from-to)302-309
JournalNature Cell Biology
Volume2
Issue number5
Publication statusPublished - 2000
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)