PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

Research output: Contribution to journalArticle

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PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. / Li, X.; Pontén, A.; Aase, K.; Karlsson, L.; Abramsson, A.; Uutela, M.; Bäckström, G.; Hellström, M.; Ehrencrona, Hans; Li, H.; Soriano, P.; Betsholtz, C.; Heldin, C. H.; Alitalo, K.; Ostman, A.; Eriksson, U.

In: Nature Cell Biology, Vol. 2, No. 5, 2000, p. 302-309.

Research output: Contribution to journalArticle

Harvard

Li, X, Pontén, A, Aase, K, Karlsson, L, Abramsson, A, Uutela, M, Bäckström, G, Hellström, M, Ehrencrona, H, Li, H, Soriano, P, Betsholtz, C, Heldin, CH, Alitalo, K, Ostman, A & Eriksson, U 2000, 'PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.', Nature Cell Biology, vol. 2, no. 5, pp. 302-309. https://doi.org/10.1038/35010579

APA

Li, X., Pontén, A., Aase, K., Karlsson, L., Abramsson, A., Uutela, M., ... Eriksson, U. (2000). PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nature Cell Biology, 2(5), 302-309. https://doi.org/10.1038/35010579

CBE

Li X, Pontén A, Aase K, Karlsson L, Abramsson A, Uutela M, Bäckström G, Hellström M, Ehrencrona H, Li H, Soriano P, Betsholtz C, Heldin CH, Alitalo K, Ostman A, Eriksson U. 2000. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nature Cell Biology. 2(5):302-309. https://doi.org/10.1038/35010579

MLA

Vancouver

Li X, Pontén A, Aase K, Karlsson L, Abramsson A, Uutela M et al. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nature Cell Biology. 2000;2(5):302-309. https://doi.org/10.1038/35010579

Author

Li, X. ; Pontén, A. ; Aase, K. ; Karlsson, L. ; Abramsson, A. ; Uutela, M. ; Bäckström, G. ; Hellström, M. ; Ehrencrona, Hans ; Li, H. ; Soriano, P. ; Betsholtz, C. ; Heldin, C. H. ; Alitalo, K. ; Ostman, A. ; Eriksson, U. / PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. In: Nature Cell Biology. 2000 ; Vol. 2, No. 5. pp. 302-309.

RIS

TY - JOUR

T1 - PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

AU - Li, X.

AU - Pontén, A.

AU - Aase, K.

AU - Karlsson, L.

AU - Abramsson, A.

AU - Uutela, M.

AU - Bäckström, G.

AU - Hellström, M.

AU - Ehrencrona, Hans

AU - Li, H.

AU - Soriano, P.

AU - Betsholtz, C.

AU - Heldin, C. H.

AU - Alitalo, K.

AU - Ostman, A.

AU - Eriksson, U.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematopoietic Stem Cell Laboratory (013022012)

PY - 2000

Y1 - 2000

N2 - Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

AB - Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

KW - Platelet-Derived Growth Factor

KW - Myocardium

KW - Molecular Sequence Data

KW - Mice

KW - Mesoderm

KW - Lymphokines

KW - Ligands

KW - Kidney

KW - Insects

KW - In Situ Hybridization

KW - Humans

KW - Developmental

KW - Gene Expression Regulation

KW - Gene Expression

KW - Epithelial Cells

KW - Endopeptidases

KW - Animals

KW - COS Cells

KW - Protein Structure

KW - Tertiary

KW - RNA

KW - Messenger

KW - Rabbits

KW - Receptor

KW - Platelet-Derived Growth Factor alpha

KW - Sequence Homology

KW - Amino Acid

KW - Transgenes

U2 - 10.1038/35010579

DO - 10.1038/35010579

M3 - Article

VL - 2

SP - 302

EP - 309

JO - Nature Cell Biology

T2 - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 5

ER -