PEGylated Amyloid Peptide Nanocontainer Delivery and Release System

Research output: Contribution to journalArticle

Abstract

A micellar nanocontainer delivery and release system is designed on the basis of a peptide-polymer conjugate. The hybrid molecules self-assemble into micelles comprising a modified amyloid peptide core surrounded by a PEG corona. The modified amyloid peptide previously studied in our group forms helical ribbons based on a beta-sheet motif and contains beta-amino acids that are excluded from the beta-sheet structure, thus being potentially useful as fibrillization inhibitors. In the model peptide-PEG hybrid system studied, enzymatic degradation using alpha-chymotrypsin leads to selective cleavage close to the PEG-peptide linkage, break up of the micelles, and release of peptides in unassociated form. The release of monomeric peptide is useful because aggregation of the released peptide into beta-sheet amyloid fibrils is not observed. This concept has considerable potential in the targeted delivery of peptides for therapeutic applications.

Details

Authors
  • V. Castelletto
  • J. E. McKendrick
  • I. W. Hamley
  • Ulf Olsson
  • Celen Cenker
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physical Chemistry
Original languageEnglish
Pages (from-to)11624-11627
JournalLangmuir
Volume26
Issue number14
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes