Peptidyl diazomethylketones as cysteine protease inhibitors structurally based upon the inhibitory centers of cystatins

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Abstract

Six new putative cysteine protease inhibitors based upon sequences of the N-terminal binding fragments of rat cystatin A, bovine cystatin C and human cystatins D and S were synthesized, inhibitory activities of these compounds against papain and bovine cathepsin B were tested. Additionally, agar well diffusion test of their antibacterial activity against Streptococcus pyogenes was performed.

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Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology
  • Medicinal Chemistry
Original languageEnglish
Pages (from-to)831-837
JournalPolish Journal of Chemistry
Volume75
Issue number6
Publication statusPublished - 2001
Publication categoryResearch
Peer-reviewedYes