Percutaneous haemodynamic and renal support in patients presenting with decompensated heart failure: A multi-centre efficacy study using the Reitan Catheter Pump (RCP)

Research output: Contribution to journalArticle

Abstract

Background: Worsening heart failure complicated by congestion, hypotension, and renal dysfunction is difficult to manage, increasingly common and predicts a poor outcome. Novel therapies are required to facilitate diuresis and implementation of disease-modifying interventions in preparation for hospital discharge. Accordingly, we investigated the haemodynamic and renal effects of the Reitan Catheter Pump (RCP) percutaneous support device in patients admitted with decompensated heart failure (DHF). Methods: This was a prospective observational study of 20 patients admitted with DHF, ejection fraction < 30%, and Cardiac index (CI) < 2.1 L/min/m2 in need of inotropic/mechanical support. Results: Patients underwent RCP support for a mean of 18.3 (±6.3) hours. The RCP increased CI from 1.84 L/min/m2 (±0.27), to 2.41 L/min/m2 (±0.45, p = 0.04), increased urine output (71 mL/h (±65) to 227 ml/h (±179) (p = 0.006) with a concomitant reduction in serum creatinine (188 μmol/L (±87) to 161 μmol/L (±78) (p = 0.0007). There were no clinically significant haemolysis, vascular injury, or thrombo-embolic complications. Conclusions: For patients admitted with DHF, the RCP improves cardiac index, diuresis and renal function without causing important complications.

Details

Authors
  • Thomas R. Keeble
  • Grigoris V. Karamasis
  • Martin T. Rothman
  • Sven Erik Ricksten
  • Markus Ferrari
  • Roger Hullin
  • Fredrik Scherstén
  • Oyvind Reitan
  • Sebastian T. Kirking
  • John G.F. Cleland
  • Elliot J. Smith
Organisations
External organisations
  • University of Gothenburg
  • Basildon and Thurrock University Hospitals
  • Anglia Ruskin University
  • Barts Health NHS Trust
  • Friedrich Schiller University Jena
  • Helios Clinic Wiesbaden (HSK)
  • Lausanne University Hospital
  • Skåne University Hospital
  • CardioBridge GmbH
  • University of Glasgow
  • Royal Brompton Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • Cardiac support, Congestion, Decompensated heart failure, Renal dysfunction
Original languageEnglish
Pages (from-to)53-58
JournalInternational Journal of Cardiology
Volume275
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes