Personalised nutrition : status and perspectives

Research output: Contribution to journalReview article

Abstract

Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations.

Details

Authors
  • Hans-Georg Joost
  • Michael J. Gibney
  • Kevin D. Cashman
  • Ulf Görman
  • John E. Hesketh
  • Michael Mueller
  • Ben van Ommen
  • Christine M. Williams
  • John C. Mathers
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Nutrition and Dietetics

Keywords

  • disease risk, genotype, nutrigenetics, nutritional recommendations, nutrigenomics
Original languageEnglish
Pages (from-to)26-31
JournalBritish Journal of Nutrition
Volume98
Issue number01
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Centre for Theology and Religious Studies (015017000)