Pharmacokinetic and biodistribution study following systemic administration of Fospeg - a Pegylated liposomal mTHPC formulation in a murine model

Research output: Contribution to journalArticle

Abstract

Abstract in Undetermined Fospeg® is a newly developed photosensitizer formulation based on meso-tetra(hydroxyphenyl)chlorin (mTHPC), with hydrophilic liposomes to carry the hydrophobic photosensitizer to the target tissue. In this study the pharmacokinetics and biodistribution of Fospeg® were investigated by high performance liquid chromatography at various times (0.5-18 hours) following systemic i.v. administration. As a model an experimental HT29 colon tumor in NMRI nu/nu mice was employed. Our study indicates a higher plasma peak concentration, a longer circulation time and a better tumor-to-skin ratio than those of Foslip®, another liposomal mTHPC formulation. Data from ex vivo tissue fluorescence and reflectance imaging exhibit good correlation with chemical extraction. Our results have shown that optical imaging provides the potential for fluorophore quantification in biological tissues. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim).

Details

Authors
Organisations
External organisations
  • Biolitec Research GmbH
  • National Technical University of Athens
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
  • Dermatology and Venereal Diseases

Keywords

  • mTHPC, Fospeg, liposomes, pharmacokinetics, biodistribution, high performance liquid chromatography, fluorescence imaging
Original languageEnglish
Pages (from-to)142-152
JournalJournal of Biophotonics
Volume8
Issue number1-2
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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