Pharmacokinetics of cytosine arabinoside in cerebrospinal fluid and of its metabolite in leukemic cells

Research output: Contribution to journalArticle

Abstract

Concentrations of ara-CTP in leukemic cells isolated from CSF and of ara-C in lumbar CSF were measured following intraventricular ara-C administration in two girls with refractory meningeal leukemia. CSF samples were collected with a permanent intrathecal-lumbar catheter. In contrast to the comparatively short retention of ara-C in the CSF (t1/2 1.8 to 2.9 hours), there was a high accumulation and an extremely long retention of ara-CTP in the leukemic cells (t1/2 8.1 to 36 hours). The patients included in this study had an ara-C-resistant disease. No obvious relationship was seen between concentrations of ara-C in the CSF and of ara-CTP in the leukemic cells. Similar studies were performed after simultaneous intraventricular administration of hydrocortison and ara-C. Hydrocortison did not increase ara-CTP retention in the leukemic cells, nor did it effect CSF pleocytosis.

Details

Authors
  • Albert Békássy
  • Jan Liliemark
  • Stanislaw Garwicz
  • Thomas Wiebe
  • Hans Gulliksson
  • Curt Peterson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics

Keywords

  • intrathecal, intraventricular, child, acute leukemia, CNS Leukemia
Original languageEnglish
Pages (from-to)136-142
JournalMedical and Pediatric Oncology
Volume18
Issue number2
Publication statusPublished - 1990
Publication categoryResearch
Peer-reviewedYes