Photoacoustic imaging for three-dimensional visualization and delineation of basal cell carcinoma in patients

Research output: Contribution to journalArticle

Abstract

Background: Photoacoustic (PA) imaging is an emerging non-invasive biomedical imaging modality that could potentially be used to determine the borders of basal cell carcinomas (BCC) preoperatively in order to reduce the need for repeated surgery.

Methods: Two- and three-dimensional PA images were obtained by scanning BCCs using 59 wavelengths in the range 680-970 nm. Spectral unmixing was performed to visualize the tumor tissue distribution. Spectral signatures from 38 BCCs and healthy tissue were compared ex vivo.

Results and discussion: The PA spectra could be used to differentiate between BCC and healthy tissue ex vivo (p < 0.05). Spectral unmixing provided visualization of the overall architecture of the lesion and its border.

Conclusion: PA imaging can be used to differentiate between BCC and healthy tissue and can potentially be used to delineate tumors prior to surgical excision.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Ophthalmology
  • Radiology, Nuclear Medicine and Medical Imaging
Original languageEnglish
Article number100187
JournalPhotoacoustics
Volume18
Publication statusPublished - 2020 Jun
Publication categoryResearch
Peer-reviewedYes