Photocoagulation of human retinal pigment epithelial cells in vitro: evaluation of necrosis, apoptosis, cell migration, cell proliferation and expression of tissue repairing and cytoprotective genes.

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Abstract

Sight-threatening diabetic retinopathy has been treated with photocoagulation for decades but the mechanisms behind the beneficial clinical effects are poorly understood. One target of irradiation and a potential player in this process is the retinal pigment epithelium (RPE). Here we establish an in vitro model for photocoagulation of human RPE cells.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Ophthalmology
  • Endocrinology and Diabetes
Original languageEnglish
Article numbere70465
JournalPLoS ONE
Volume8
Issue number8
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510), Ophthalmology (013242810), Department of Clinical Sciences, Malmö (013240000)

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