Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC

Research output: Contribution to journalArticle

Abstract

The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by <SU32</SUP-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 mu mol GSH g<SU-1</SU haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.</.

Details

Authors
  • Andrew Rundle
  • John Richie
  • Karen Steindorf
  • Marco Peluso
  • Kim Overvad
  • Ole Raaschou-Nielsen
  • Francoise Clavel-Chapelon
  • Jacob P. Linseisen
  • Heiner Boeing
  • Antonia Trichopoulou
  • Domenico Palli
  • Vittorio Krogh
  • Rosario Tumino
  • Salvatore Panico
  • Hendrik B. Bueno-De-Mesquita
  • Petra H. Peeters
  • Eiliv Lund
  • Carlos A. Gonzalez
  • Carmen Martinez
  • Miren Dorronsoro
  • And 13 others
  • Aurelio Barricarte
  • M. Jose Tormo
  • Jose R. Quiros
  • Antonio Agudo
  • Göran Berglund
  • Bengt Jarvholm
  • Sheila Bingham
  • Timothy J. Key
  • Emmanuelle Gormally
  • Rodolfo Saracci
  • Rudolf Kaaks
  • Elio Riboli
  • Paolo Vineis
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Other Clinical Medicine

Keywords

  • biomarkers, Physical activity, lung cancer, molecular epidemiology
Original languageEnglish
Pages (from-to)20-30
JournalBiomarkers
Volume15
Issue number1
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes