Physical activity and lymphoid neoplasms in the European Prospective Investigation into Cancer and nutrition (EPIC)

Research output: Contribution to journalArticle

Abstract

Background: Lymphoid neoplasms are a heterogeneous group of cancers that originate in the lymphatic cells of the immune system. Several risk factors have been identified or suggested, but they all account for only a small proportion of the lymphoid neoplasm incidence. It has been hypothesised that regular exercise may modulate the immune system and thereby reduce the risk of developing the disease. Design and methods: The European Investigation into Cancer and Nutrition (EPIC) cohort consists of 521,457 adults, recruited by 23 centres in 10 European countries. The analytical cohort included 343,756 participants, with 778 non-Hodgkin lymphoma (NHL) cases (376 men and 402 women) and 690 B-cell non-Hodgkin lymphoma (B-NHL) cases (326 men and 364 women). Multivariate Cox regression models were used to calculate hazard ratios (HR) for the association between total, recreational, occupational, and household physical activity and NHL and B-NHL risk, as well as the risk for several B-NHL subtypes. Models were stratified by study centre and age at recruitment and adjusted for various potential confounding factors. Results: We found no evidence of any effect of total physical activity on NHL (adjusted p-trend = 0.76 and 0.30 for men and women, respectively) and B-NHL risk (adjusted p-trend = 0.99 and 0.21 for men and women, respectively) for either men or women. Also no robust results were found for B-NHL subtype analyses among men or women. Conclusions: This study provided no consistent evidence for an association between various physical activity measures and the risk of lymphoid neoplasms or any of the B-NHL subtypes. (C) 2010 Elsevier Ltd. All rights reserved.

Details

Authors
  • Catharina M. van Veklhoven
  • Aneire E. Khan
  • Birgit Teucher
  • Sabine Rohrmann
  • Ole Raaschou-Nielsen
  • Anne Tjonneland
  • Kim Overvad
  • Matthaeus Vigl
  • Heiner Boeing
  • Vassiliki Benetou
  • Antonia Trichopoulou
  • Dimitrios Trichopoulos
  • Giovanna Masala
  • Amalia Mattiello
  • Vittorio Krogh
  • Rosario Tumino
  • Roel Vermeulen
  • Evelyn Monninkhof
  • Anne M. May
  • Bas Bueno-de-Mesquita
  • Eiliv Lund
  • Eva Ardanaz
  • Jose Maria Huerta
  • Paula Jakszyn
  • Miren Dorronsoro
  • Marcial Argueelles
  • Maria-Jose Sanchez
  • Goran Hallmans
  • Naomi E. Allen
  • Ruth C. Travis
  • Kay Tee Khaw
  • Nick Wareham
  • Paolo Boffetta
  • Paolo Vineis
  • Elio Riboli
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery
  • Cancer and Oncology

Keywords

  • Lymphoid neoplasm, Hodgkin lymphoma, Non-Hodgkin lymphoma, Multiple, myeloma, Lymphocytic leukaemia, Physical activity, Cohort study
Original languageEnglish
Pages (from-to)748-760
JournalEuropean Journal of Cancer
Volume47
Issue number5
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes