Physical inactivity increases the risk of endometrial cancer and premenopausal breast cancer

Research output: Contribution to journalPublished meeting abstract

Abstract

Background. Epidemiological studies indicate that physical activity reduces the risk of cancer. Physical inactivity or sedentary behavior, has recently been suggested as a risk factor independent of physical activity level. Breast and endometrial cancer incidence have both been associated with physical activity, and endometrial cancer incidence with physical inactivity/sedentary behavior. The purpose of the present study was to investigate physical inactivity as a risk factor for breast cancer, divided into pre- and postmenopausal subtypes, and for endometrial cancer, and to explore possible dose-response relations regarding the level of physical inactivity. Methods. In a population-based prospective cohort study, 29 520 women in the southern part of Sweden, in ages between 25 and 64 years, participated. A questionnaire-based survey was performed 1990-92. Their reported professions were classified as sedentary or not which together with reported participation in competitive sports constituted the basis for classification into three activity-levels; (1) physical inactivity, defined as having sedentary occupation and no participation in competitive sports, (2) partly inactive, defined as either having a sedentary occupation or non- participation in competitive sports, (3) Physical active, defined as not having a sedentary occupation and participation in competitive sports. The association between physical inactivity and pre and postmenopausal breast and endometrial cancer incidence were analyzed by Cox regression, adjusted for hormonal factors, family history of cancer, body mass index (BMI) and age. Results. Physical inactive women had a significantly increased risk of endometrial cancer (HR = 2.41, 95% CI 1.14-5.11) and premenopausal breast cancer (HR = 2.40, 95% CI 1.14-5.02), compared with women who were less physical inactive. No such association was found for postmenopausal breast cancer. Analysis of linear trend showed a significant dose-response relationship with increased risk of both premenopausal breast cancer (ptrend 0.02) and endometrial cancer (ptrend

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • risk, endometrium cancer, breast cancer, American, cancer research, physical inactivity, physical activity, sport, occupation, human, female, cancer incidence, dose response, breast, neoplasm, risk factor, body mass, family history, proportional hazards model, classification, questionnaire, Sweden, cohort analysis, population
Original languageEnglish
Article numberAbstract 865
JournalCancer Research
Volume75
Issue number15 Suppl
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes
EventAmerican Association for Cancer Research (AACR) 106th Annual Meeting 2015 - Pennsylvania Convention Center, Philadelphia, United States
Duration: 2015 Apr 182015 Apr 22
Conference number: 106
http://www.aacr.org/Meetings/Pages/MeetingDetail.aspx?EventItemID=25