Plants salvage deoxyribonucleosides in mitochondria.

Research output: Contribution to journalArticle

Abstract

Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower activity and chloroplasts contained no measurable activities. In addition, a mitochondrial fraction isolated from the potato Solanum tuberosum contained thymidine kinase and deoxyadenosine kinase activities. We conclude that an active salvage of deoxyribonucleosides in plants takes place in their mitochondria. In general, the observed localization of the plant dNK activities in the mitochondrion suggests that plants have a different organization of the deoxyribonucleoside salvage compared to mammals.

Details

Authors
  • Anders Ranegaard Clausen
  • Zeeshan Mutahir
  • Birgitte Munch-Petersen
  • Jure Piskur
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biological Sciences
Original languageEnglish
Pages (from-to)291-295
JournalNucleosides, Nucleotides & Nucleic Acids
Volume33
Issue number4-6
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes