Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition

Research output: Contribution to journalArticle


Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >= 2y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.


  • Anna Luczynska
  • Rudolf Kaaks
  • Sabine Rohrmann
  • Susen Becker
  • Jakob Linseisen
  • Brian Buijsse
  • Kim Overvad
  • Antonia Trichopoulou
  • Elisavet Valanou
  • Antonia Barmpitsioti
  • Giovanna Masala
  • Claudia Agnoli
  • Rosario Tumino
  • Salvatore Panico
  • H. Bas Bueno-de-Mesquita
  • Franzel J. B. van Duijnhoven
  • Petra H. M. Peeters
  • Roel Vernieulen
  • Elisabete Weiderpass
  • Magritt Brustad
  • Guri Skeie
  • Carlos A. Gonzalez
  • Paula Jakszyn
  • J. Ramon Quiros
  • Maria-Jose Sanchez
  • Jose-Maria Huerta
  • Eva Ardanaz
  • Beatrice Melin
  • Ann Sofie Johansson
  • Kay-Tee Khaw
  • Nick Wareham
  • Ruth C. Travis
  • Veronika Fedirko
  • Isabelle Romieu
  • Mazda Jenab
  • Valentina Gallo
  • Elio Riboli
  • Paolo Vineis
  • Alexandra Nieters
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Nutrition and Dietetics
Original languageEnglish
Pages (from-to)827-838
JournalAmerican Journal of Clinical Nutrition
Issue number3
Publication statusPublished - 2013
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Clinical Chemistry, Malmö (013016000)