Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

Research output: Contribution to journalArticle

Bibtex

@article{08264e4557e6420faf88596af84e5115,
title = "Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies",
abstract = "Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.",
author = "Grigorios Kalapotharakos and Katja Murtoniemi and Bo {\AA}kerstr{\"o}m and Esa H{\"a}m{\"a}l{\"a}inen and Eero Kajantie and Katri R{\"a}ikk{\"o}nen and Pia Villa and Hannele Laivuori and Hansson, {Stefan R}",
year = "2019",
doi = "10.3389/fphys.2019.00300",
language = "English",
volume = "10",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Media S. A.",

}