Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals

Research output: Contribution to journalArticle

Abstract

Introduction: Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. However, there are limited reports of how longitudinal NfL relates to imaging biomarkers. We herein investigated the relationship between blood NfL and brain metabolism in AD. Methods: Voxelwise regression models tested the cross-sectional association between [18F]fluorodeoxyglucose ([18F]FDG) and both plasma and cerebrospinal fluid NfL in cognitively impaired and unimpaired subjects. Linear mixed models were also used to test the longitudinal association between NfL and [18F]FDG in amyloid positive (Aβ+) and negative (Aβ−) subjects. Results: Higher concentrations of plasma and cerebrospinal fluid NfL were associated with reduced [18F]FDG uptake in correspondent brain regions. In Aβ+ participants, NfL associates with hypometabolism in AD-vulnerable regions. Longitudinal changes in the association [18F]FDG-NfL were confined to cognitively impaired Aβ+ individuals. Discussion: These findings indicate that plasma NfL is a proxy for neurodegeneration in AD-related regions in Aβ+ subjects.

Details

Authors
  • Alzheimer's Disease Neuroimaging Initiative
  • Andréa L. Benedet
  • Nicholas J. Ashton
  • Tharick A. Pascoal
  • Antoine Leuzy
  • Sulantha Mathotaarachchi
  • Min S. Kang
  • Joseph Therriault
  • Melissa Savard
  • Mira Chamoun
  • Michael Schöll
  • Eduardo R. Zimmer
  • Serge Gauthier
  • Aurélie Labbe
  • Henrik Zetterberg
  • Kaj Blennow
  • Pedro R. Neto
Organisations
External organisations
  • Ministry of Education of Brazil
  • King's College London
  • University College London
  • University of Gothenburg
  • Federal University of Rio Grande do Sul
  • HEC Montreal
  • Sahlgrenska University Hospital
  • McGill University
  • NIHR Maudsley Biomedical Research Centre
  • Montreal Neurological Institute & Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Alzheimer's disease, Biomarkers, Blood, Hypometabolism, Longitudinal, Neurodegeneration, Neurofilament light, PET, [F]FDG
Original languageEnglish
Pages (from-to)679-689
Number of pages11
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes