Plasma Protein Layer Concealment Protects Streptococcus pyogenes From Innate Immune Attack

Research output: Contribution to journalArticle

Abstract

Early recognition and elimination of invading pathogens by the innate immune system, is one of the most efficient host defense mechanisms preventing the induction of systemic complications from infection. To this end the host can mobilize endogenous antimicrobials capable of killing the intruder by perforating the microbial cell wall. Here, we show that Streptococcus pyogenes can shield its outer surface with a layer of plasma proteins. This mechanism protects the bacteria from an otherwise lytic attack by LL-37 and extracellular histones, allowing the bacteria to adjust their gene regulation to an otherwise hostile environment.

Details

Authors
Organisations
External organisations
  • University College Dublin
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine

Keywords

  • antibiotic resistance, antimicrobials, cold atmospheric plasma (CAP), hemostasis, innate immune system, Streptococcus pyogenes (GAS)
Original languageEnglish
Article number633394
JournalFrontiers in cellular and infection microbiology
Volume11
Publication statusPublished - 2021 May 20
Publication categoryResearch
Peer-reviewedYes