Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukaemia patients stopping tyrosine kinase inhibitor therapy

Research output: Contribution to journalArticle

Abstract

Several studies have now shown that chronic myeloid leukaemia (CML) patients in deep molecular remission may discontinue tyrosine kinase inhibitor (TKI) treatment with a treatment free remission (TFR) rate of approximately 40–60 %. Some factors influencing the possibility of TFR have been described but better tools are needed for individual prediction of long-term TFR. Herein, two multiplex panels were utilised to analyse a total of 162 different plasma proteins from 56 patients included in the TKI stopping trial EURO-SKI (Saussele et al., 2018). The purpose was to identify possible plasma protein markers for prediction of successful TKI discontinuation and to evaluate effects of TKI discontinuation on plasma protein profiles. No protein biomarkers sampled before TKI discontinuation could separate relapse cases from non-relapse cases but some plasma proteins differed between patients who relapsed and those who remained in TFR when followed over time after TKI cessation. In conclusion, the plasma protein markers in this study could not predict relapse after TKI discontinuation but may be of use to understand the mechanisms involved in maintenance of TFR.

Details

Authors
  • Stina Söderlund
  • Inger Persson
  • Mette Ilander
  • Joëlle Guilhot
  • Henrik Hjorth-Hansen
  • Perttu Koskenvesa
  • Johan Richter
  • Susanne Saussele
  • Satu Mustjoki
  • Ulla Olsson-Strömberg
External organisations
  • Uppsala University
  • Uppsala University Hospital
  • Helsinki University Central Hospital
  • Helsinki University of Technology
  • Poitiers University Hospital
  • St. Olav’s University Hospital
  • Skåne University Hospital
  • Heidelberg University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • Chronic myeloid leukemia, Immunology, Proteomics, Treatment free remission, Tyrosine kinase inhibitor
Original languageEnglish
Article number106310
JournalLeukemia Research
Volume90
Publication statusPublished - 2020
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes