Plasmodium parasites of birds have the most AT-rich genes of eukaryotes

Research output: Contribution to journalArticle


title = "Plasmodium parasites of birds have the most AT-rich genes of eukaryotes",
abstract = "The genomic architecture of organisms, including nucleotide composition, can be highly variable, even among closely-related species. To better understand the causes leading to structural variation in genomes, information on distinct and diverse genomic features is needed. Malaria parasites are known for encompassing a wide range of genomic GC-content and it has long been thought that Plasmodium falciparum, the virulent malaria parasite of humans, has the most AT-biased eukaryotic genome. Here, I perform comparative genomic analyses of the most AT-rich eukaryotes sequenced to date, and show that the avian malaria parasites Plasmodium gallinaceum, P. ashfordi, and P. relictum have the most extreme coding sequences in terms of AT-bias. Their mean GC-content is 21.21, 21.22 and 21.60 {\%}, respectively, which is considerably lower than the transcriptome of P. falciparum (23.79 {\%}) and other eukaryotes. This information enables a better understanding of genome evolution and raises the question of how certain organisms are able to prosper despite severe compositional constraints.",
keywords = "GC-content, genome evolution, AT-bias",
author = "Elin Videvall",
year = "2018",
month = "1",
day = "23",
doi = "10.1099/mgen.0.000150",
language = "English",
journal = "Microbial Genomics",
issn = "2057-5858",
publisher = "Microbiology Society",