Platelet and leukocyte activation during aortoiliac angiography and angioplasty.

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Abstract

OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive granulocytes, CD18 expression on granulocytes, plasma (p)-neopterin, p-TNF alpha and p- interleukin-6 were repeatedly measured in arterial blood during angiography and in venous blood before and after. RESULTS: compared to a previous venous sample, arterial intraplatelet cAMP was increased proximal to the atherosclerotic lesion before contrast infusion and PTA (median 18 [range: 14-22] vs 16 [15-21] pmol/10(9) platelets p<0.05), and intraplatelet cGMP was increased proximal to the lesion after contrast infusion and PTA (1.2 [0.8-3.9] vs 0.9 [0.6-2.5] pmol/10(9) platelets p<0.05). Four hours after angiography, both the proportion of P-selectin positive platelets (28[11-55]%) and platelet P-selectin expression (9[6-40]) had decreased (p<0.05), from arterial values distal to the lesion before contrast infusion and PTA (57 [24-78]% and 26 [10-83]). Granulocyte CD18 expression was lower during angiography than in a previous venous sample. CONCLUSIONS: the results are compatible with platelet but not leukocyte activation during peripheral angiography.

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Subject classification (UKÄ) – MANDATORY

  • Surgery

Keywords

  • Iliac Artery : physiopathology, Iliac Artery : radiography, Female, Contrast Media : pharmacology, Arteriosclerosis : therapy, Arteriosclerosis : physiopathology, Aortography, Aorta : physiopathology, Aorta : drug effects, Balloon, Angiography, Angioplasty, 80 and over, Aged, Leukocytes : drug effects, Male, Leukocytes : physiology, Iliac Artery : drug effects, Human, Middle Age, Platelet Activation : drug effects, Platelet Activation : physiology
Original languageEnglish
Pages (from-to)220-225
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume23
Issue number3
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes