Platelet-derived S100A8/A9 and cardiovascular disease in systemic lupus erythematosus.

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Abstract

S100A8/A9, a pro-inflammatory and pro-thrombotic protein complex, is increased in several diseases and high levels predispose to cardiovascular disease (CVD). Recently, platelet S100A8/A9 synthesis was described in mouse and humans in relation to CVD. However, the role of platelet S100A8/A9 in systemic lupus erythematosus (SLE), a disease with markedly increased cardiovascular morbidity, as well as the exact platelet distribution of the S100A8/A9 proteins has not been investigated.

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  • Cell and Molecular Biology
Original languageEnglish
JournalArthritis & Rheumatology
Early online date2016 Mar 4
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes