Platelets and innate immunity

Research output: Contribution to journalArticle

Abstract

Although platelets are best known as primary mediators of hemostasis, this function intimately associates them with inflammatory processes, and it has been increasingly recognized that platelets play an active role in both innate and adaptive immunity. For example, platelet adhesive interactions with leukocytes and endothelial cells via P-selectin can lead to several pro-inflammatory events, including leukocyte rolling and activation, production of cytokine cascades, and recruitment of the leukocytes to sites of tissue damage. Superimposed on this, platelets express immunologically-related molecules such as CD40L and Toll-like receptors that have been shown to functionally modulate innate immunity. Furthermore, platelets themselves can interact with microorganisms, and several viruses have been shown to cross-react immunologically with platelet antigens. This review discusses the central role that platelets play in inflammation, linking them with varied pathological conditions, such as atherosclerosis, sepsis, and immune thrombocytopenic purpura, and suggests that platelets also act as primary mediators of our innate defences.

Details

Authors
External organisations
  • Li Ka Shing Knowledge Institute
Research areas and keywords

Keywords

  • Acute Lung Injury, Adaptive Immunity, Atherosclerosis, Blood Platelets, Humans, Immunity, Innate, Inflammation, Membrane Glycoproteins, Neutrophils, Platelet Transfusion, Receptors, Immunologic, Sepsis, Toll-Like Receptors, Journal Article, Review
Original languageEnglish
Pages (from-to)499-511
JournalCellular and Molecular Life Sciences
Volume67
Issue number4
Publication statusPublished - 2010 Feb
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes