Platinum, palladium, rhodium, molybdenum and strontium in blood of urban women in nine countries

Research output: Contribution to journalArticle

Abstract

Background: There is little reliable information on human exposure to the metals platinum (Pt), palladium (Pd) and rhodium (Rh), despite their use in enormous quantities in catalytic converters for automobile exhaust systems. Objectives: To evaluate blood concentrations of Pt (B-Pt), Pd (B-Pd) and Rh (B-Rh) in women from six European and three non-European countries, and to identify potentially influential factors. In addition, molybdenum (Mo) and strontium (Sr) were analysed. Methods: Blood from 248 women aged 47-61 was analysed by high resolution inductively coupled plasma mass spectrometry under strict quality control. Results: The medians were: B-Pt 0.8 (range <0.6-5.2), B-Pd <5 (<5-9.3), B-Rh <0.4 (<0.4-3.6). ng/L and B-Mo 2.0 (0.2-16) and B-Sr 16.6 (3.5-49) μg/L. Two women with highly elevated B-Pt (242 and 60. ng/L), previously cancer treated with cis-platinum, were not included in the data analysis. All elements varied geographically (2-3 times) (B-Pd P = 0.05; all other elements P. <. 0.001); variations within each area were generally 5-10 times. Traffic was not associated with increased concentrations. Conclusions: General population blood concentrations of Pt, Pd and Rh are within or below the single digit ng/L range, much lower than in most previous reports. This is probably due to improved analytical performance, allowing for more reliable information at ultra-trace levels. In general, Mo and Sr agreed with previously reported concentrations. All elements showed geographical and inter-individual variations, but no convincing relationships with self-reported traffic intensity were found. Pt from the antineoplastic drug cis-platinum is retained in the body for years.

Details

Authors
  • Gerda Rentschler
  • Ilia Rodushkin
  • Milena Cerna
  • Chunying Chen
  • Florencia Harari
  • Raúl Harari
  • Milena Horvat
  • Frantiska Hruba
  • Lucie Kasparova
  • Kvetoslava Koppova
  • Andrea Krskova
  • Mladen Krsnik
  • Jawhar Laamech
  • Yu Feng Li
  • Lina Löfmark
  • Nils Göran Lundström
  • Badiaa Lyoussi
  • Darja Mazej
  • Josko Osredkar
  • Krystyna Pawlas
  • Natalia Pawlas
  • Adam Prokopowicz
  • Janja Snoj Tratnik
  • Vera Spevackova
  • Zdravko Spiric
  • Anneli Sundkvist
  • Drazenka Vadla
  • Katerina Wranova
  • Soumia Zizi
  • Ingvar A. Bergdahl
Organisations
External organisations
  • ALS Scandinavia AB
  • Charles University in Prague
  • Institute of High Energy Physics, Chinese Academy of Science
  • Institute for the Development of Production and the Work Environment
  • Jožef Stefan Institute
  • State Institute of Public Health Slovakia
  • National Institute of Public Health-National Institute of Hygiene, Poland
  • Slovak Medical University
  • University Medical Centre Ljubljana
  • Sidi Mohamed Ben Abdellah University
  • Umeå University
  • Institute of Occupational Medicine and Environmental Health
  • Medical University of Silesia
  • Oikon Ltd. - Institute of Applied Ecology
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Environmental Health and Occupational Health

Keywords

  • Biomarkers, Biomonitoring, Catalytic converters, Cis-platinum, High-resolution ICP-MS, Human, Metals, Traffic, Women
Original languageEnglish
Pages (from-to)223-230
JournalInternational Journal of Hygiene and Environmental Health
Volume221
Issue number2
Early online date2017 Nov 1
Publication statusPublished - 2018
Publication categoryResearch
Peer-reviewedYes