Ploidy and clinical characteristics of childhood acute myeloid leukemia: A NOPHO-AML study

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Abstract

We report the first large series (n=596) of pediatric acute myeloid leukemia (AML) focusing on modal numbers (MN) from the population-based NOPHO-AML trials. Abnormal karyotypes were present in 452 cases (76%) and numerical aberrations were present in 40% (n=237) of all pediatric AML. Among patients with an abnormal karyotype, the MN 46 was most common (n=251; 56%) of which 36 (8%) were pseudodiploid with numerical aberrations, followed by MN 47 (n=80; 18%) and MN 43-45 (n=48; 8%). No cases had MN less than 43. Hyperdiploid AML with MN 48-65 comprised 11% of all cases and was associated with early onset (median age 2 years), female sex (57%), and a dominance of acute megakaryoblastic leukemia (AMKL) (29%). Hypodiploidy constituted 8% of all AML and was associated with older age (median age 9 years), male predominance (60%), FAB M2 (56%), and t(8;21)(q22;q22) (56%) with loss of sex chromosomes. Inferior outcome was observed for hypodiploid cases (5-year event-free survival 40% and 5-year overall survival 40%) but did not reach statistical significance. Chromosomes were gained in a nonrandom pattern, where chromosomes 8, 21, 19, and 6 were the most commonly gained. In conclusion, based on MNs, two cytogenetic subgroups with characteristic clinical features are described; hypodiploidy found in 8% and associated with high median age, male sex, t(8;21)(q22;q22), and FAB M2 and possibly associated with inferior outcome (P=0.13), and hyperdiploidy with MN 48-65 in 11% associated with early onset, female sex, and AMKL. (c) 2014 Wiley Periodicals, Inc.

Details

Authors
  • Julie Damgaard Sandahl
  • Eigil Kjeldsen
  • Jonas Abrahamsson
  • Shau-Yin Ha
  • Jesper Heldrup
  • Kirsi Jahnukainen
  • Olafur G. Jonsson
  • Birgitte Lausen
  • Josefine Palle
  • Bernward Zeller
  • Erik Forestier
  • Henrik Hasle
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics
Original languageEnglish
Pages (from-to)667-675
JournalGenes, Chromosomes and Cancer
Volume53
Issue number8
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes