Polyketide synthesis genes associated with toxin production in two species of Gambierdiscus (Dinophyceae).

Research output: Contribution to journalArticle

Abstract

Marine microbial protists, in particular, dinoflagellates, produce polyketide toxins with ecosystem-wide and human health impacts. Species of Gambierdiscus produce the polyether ladder compounds ciguatoxins and maitotoxins, which can lead to ciguatera fish poisoning, a serious human illness associated with reef fish consumption. Genes associated with the biosynthesis of polyether ladder compounds are yet to be elucidated, however, stable isotope feeding studies of such compounds consistently support their polyketide origin indicating that polyketide synthases are involved in their biosynthesis.

Details

Authors
  • Gurjeet S Kohli
  • Uwe John
  • Rosa Figueroa
  • Lesley L Rhodes
  • D Tim Harwood
  • Marco Groth
  • Christopher J S Bolch
  • Shauna A Murray
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Genetics
Original languageEnglish
Article number410
JournalBMC Genomics
Volume16
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes