Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project

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@article{27f1a25095f845848a92b94871dee36d,
title = "Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project",
abstract = "OBJECTIVE: To study the association between polymorphisms in the angiotensin converting enzyme (ACE) gene and angiotensinogen (AGT) gene and hypertension and/or type 2 diabetes in a community population. PATIENTS AND METHODS: The insertion (I)/deletion (D) polymorphism of the ACE gene and the M235T polymorphism of the AGT gene were genotyped in 773 nondiabetic individuals with hypertension, 193 normotensive patients with type 2 diabetes, 243 patients with type 2 diabetes and hypertension, and in 820 normotensive control individuals identified in a community-based study. RESULTS: The DD genotype was associated with hypertension in individuals less than 70 years [odds ratio (OR) = 1.54, confidence interval (CI) = 1.09-2.18] and remained so when patients with type 2 diabetes were excluded from the analysis (OR = 1.45, CI = 1.01-2.09). The strongest association was with the combination of type 2 diabetes and hypertension (OR = 2.19, CI = 1.09-4.38). There was no association with type 2 diabetes without hypertension. No association was observed between the M235T variant or the 3'-microsatellite polymorphism of the AGT gene and hypertension. CONCLUSION: The D-allele of the ACE gene ID polymorphism increases susceptibility to hypertension, particularly when associated with type 2 diabetes. No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.",
keywords = "Hypertension, Diabetes mellitus, Polymorphism, Peptidyl-dipeptidase A, Gene, Angiotensinogen, Genetic determinism, Human, Peptidyl-dipeptidases, Peptidases, Hydrolases, Enzyme, Cardiovascular disease, Endocrinopathy",
author = "{Bengtsson Bostr{\"o}m}, Kristina and Marju Orho-Melander and Ulf Lindblad and Olle Melander and Erik B{\o}g-Hansen and Jonas Ranstam and Lennart R{\aa}stam and Leif Groop",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Community Medicine (013241810), Diabetes and Endocrinology (013241530), Hypertension and Cardiovascular Disease (013242540), Psychiatry/Primary Care/Public Health (013240500), Department of Orthopaedics (Lund) (013028000)",
year = "1999",
language = "English",
volume = "17",
pages = "1569--1575",
journal = "Journal of Hypertension",
issn = "1473-5598",
publisher = "Lippincott Williams & Wilkins",
number = "11",

}