Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.
Research output: Contribution to journal › Article
The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Fertility and Sterility|
|Publication status||Published - 2010|