Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.

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Abstract

The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).

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  • Obstetrics, Gynecology and Reproductive Medicine
Original languageEnglish
Pages (from-to)277-279
JournalFertility and Sterility
Volume93
Issue number1
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes