Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.

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Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure. / Bungum, Mona; Giwercman, Aleksander; Bungum, Leif; Humaidan, Peter; Rastkhani, Hamideh; Giwercman, Yvonne.

In: Fertility and Sterility, Vol. 93, No. 1, 2010, p. 277-279.

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TY - JOUR

T1 - Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.

AU - Bungum, Mona

AU - Giwercman, Aleksander

AU - Bungum, Leif

AU - Humaidan, Peter

AU - Rastkhani, Hamideh

AU - Giwercman, Yvonne

PY - 2010

Y1 - 2010

N2 - The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).

AB - The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).

U2 - 10.1016/j.fertnstert.2009.07.984

DO - 10.1016/j.fertnstert.2009.07.984

M3 - Article

VL - 93

SP - 277

EP - 279

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 1556-5653

IS - 1

ER -