Population genetics of the Malmö polymorphism of coagulation factor IX

Research output: Contribution to journalArticle

Abstract

The distribution of 1.198 Malmö alleles was examined in 822 men from 16 indigenous populations and 188 women from 7 of the ethnic groups. Subjects were from several European countries, the Mediterranean, East Asia, and the USA (Anglo- and African-Americans). The frequencies of the rarer (Malmö B) allele were approximately equal across Europe, the highest frequencies (0.36) being in the French and Anglo-Americans; no population was observed with clearly the highest frequency. They diminished slightly at moderate distances from Europe (Tunisia. Ethiopia) and greatly at longer distances (East Asia and West Africa). In Orientals, the frequencies ranged from 0.07 (East Indians) to 0.03 (the Chinese) and from 0.0 to 0.15 in African-Americans. Assuming selective neutrality, the data are consistent with the European origin of the ‘B’ allele when the population was small and outward spread.

Details

Authors
Organisations
External organisations
  • University of North Carolina
  • University of Tunis
  • University of Malaya
Research areas and keywords

Keywords

  • Factor IX, Malmö polymorphism, Population genetics
Original languageEnglish
Pages (from-to)391-396
JournalHuman Heredity
Volume41
Issue number6
Publication statusPublished - 1991
Publication categoryResearch
Peer-reviewedYes