Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD.

Research output: Contribution to journalArticle

Abstract

Epidemiological studies have indicated that chronic obstructive pulmonary disease (COPD) may be associated with an increased incidence of ischaemic cardiac events. The current authors performed a post hoc analysis of the European Respiratory Society's study on Chronic Obstructive Pulmonary Disease (EUROSCOP); a 3-yr, placebo-controlled study of an inhaled corticosteroid budesonide 800 pg-day-1 in smokers (mean age 52 yrs) with mild COPD. The current study evaluates whether long-term budesonide treatment attenuates the incidence of ischaernic cardiac events, including angina pectorls, myocardial infarction, coronary artery disorder and myocardial ischaemia. Among the 1,175 patients evaluated for safety, 49 (4.2%) patients experienced 60 ischaernic cardiac events. Patients treated with budesonide had a significantly lower incidence of ischaernic cardiac events (18 out of 593; 3.0%) than those receiving placebo (31 out of 582; 5.3%). The results of the present study support the hypothesis that treatment with inhaled budesonide reduces ischaernic cardiac events in patients with mild chronic obstructive pulmonary disease.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Respiratory Medicine and Allergy

Keywords

  • chronic obstructive pulmonary disease, ischaemic cardiac, events, budesonide
Original languageEnglish
Pages (from-to)1115-1119
JournalEuropean Respiratory Journal
Volume29
Issue number6
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes