Postprandial Glucagon Reductions Correlate to Reductions in Postprandial Glucose and Glycated Hemoglobin with Lixisenatide Treatment in Type 2 Diabetes Mellitus: A Post Hoc Analysis

Research output: Contribution to journalArticle

Abstract

Introduction: The extent to which postprandial glucagon reductions contribute to lowering of postprandial glucose in patients with type 2 diabetes mellitus (T2DM) is currently unknown. The aim of this analysis was to determine whether a reduction in postprandial glucagon following treatment with the glucagon-like peptide-1 receptor agonist lixisenatide correlates with a reduction in postprandial glucose and glycated hemoglobin (HbA1c) in patients with T2DM. Methods: A post hoc analysis was performed on pooled data from the modified intent-to-treat populations of two lixisenatide Phase 3 trials: GetGoal-M (lixisenatide versus placebo as add-on to metformin) and GetGoal-S (lixisenatide versus placebo as add-on to sulfonylurea [SU] ± metformin). Glucagon levels were assessed 2 h after a standardized meal test performed at baseline and Week 24 and were examined for correlation with changes in 2-h postprandial glucose and HbA1c. Results: Lixisenatide reduced 2-h postprandial glucagon at Week 24 compared with placebo (P < 0.00001). The mean change in postprandial glucagon significantly correlated with reductions in postprandial glucose (P < 0.00001) and HbA1c (P < 0.00001). Conclusion: A reduction in postprandial glucagon following lixisenatide administration correlated with a decrease in postprandial glucose and HbA1c in patients with T2DM insufficiently controlled on metformin and/or SU. This suggests that lowering of postprandial glucagon contributes to the overall glycemic improvement observed with lixisenatide. Funding: Sanofi. Clinical Trial Numbers: NCT00712673 (GetGoal-M) and NCT00713830 (GetGoal-S).

Details

Authors
  • Bo Ahrén
  • Gagik Galstyan
  • Jean Francois Gautier
  • Francesco Giorgino
  • Fernando Gomez-Peralta
  • Michael Krebs
  • Elena Nikonova
  • William Stager
  • Hernando Vargas-Uricoechea
Organisations
External organisations
  • National Centre of Endocrinology, Moscow
  • Lariboisière Hospital
  • University of Bari Aldo Moro
  • Hospital General de Segovia
  • Medical University of Vienna
  • Artech Information Systems, LLC
  • Sanofi-Aventis
  • Hospital Universitario San José
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes

Keywords

  • Glucagon, Glucagon-like peptide-1 receptor agonist, Glycemic control, Lixisenatide, Prandial, Type 2 diabetes mellitus
Original languageEnglish
Pages (from-to)583-590
Number of pages8
JournalDiabetes Therapy
Volume7
Issue number3
Publication statusPublished - 2016 Sep 1
Publication categoryResearch
Peer-reviewedYes