Power Cut: Inhibiting Mitochondrial Translation to Target Leukemia

Research output: Contribution to journalArticle

Abstract

In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.

Details

Authors
External organisations
  • Brigham and Women's Hospital / Harvard Medical School
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)555-556
Number of pages2
JournalCancer Cell
Volume20
Issue number5
Publication statusPublished - 2011 Nov 15
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes