Power Cut: Inhibiting Mitochondrial Translation to Target Leukemia
Research output: Contribution to journal › Article
In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Number of pages||2|
|Publication status||Published - 2011 Nov 15|