Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations

Research output: Contribution to journalArticle

Abstract

General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (FIRS) and corresponding 95% confidence intervals (as). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, prediagnostic BMI kg/m2 was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI <25 kg/m(2). Every 5 kg/m(2) increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% Cl = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% Cl = 1.02-1.16) and allcause death (HR= 1.11, 95% CI= 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.

Details

Authors
  • Veronika Fedirko
  • Isabelle Romieu
  • Krasimira Aleksandrova
  • Tobias Pischon
  • Dimitrios Trichopoulos
  • Petra H. Peeters
  • Dora Romaguera-Bosch
  • H. B(as) Bueno-de-Mesquita
  • Christina C. Dahm
  • Kim Overvad
  • Maria-Dolores Chirlaque
  • Christoffer Johansen
  • Pernille E. Bidstrup
  • Susanne O. Dalton
  • Marc J. Gunter
  • Petra A. Wark
  • Teresa Norat
  • Jytte Halkjaer
  • Anne Tjonneland
  • Vincent K. Dik
  • Peter D. Siersema
  • Marie-Christine Boutron-Ruault
  • Laure Dossus
  • Nadia Bastide
  • Tilman Kuehn
  • Rudolf Kaaks
  • Heiner Boeing
  • Antonia Trichopoulou
  • Eleni Klinaki
  • Michalis Katsoulis
  • Valeria Pala
  • Salvatore Panico
  • Rosario Tumino
  • Domenico Palli
  • Paolo Vineis
  • Elisabete Weiderpass
  • Guri Skeie
  • Carlos A. Gonzalez
  • Maria-Jose Sanchez
  • Aurelio Barricarte
  • Pilar Amiano
  • J. Ramon Quiros
  • Ingrid Ljuslinder
  • Richard Palmqvist
  • Kay-Tee Khaw
  • Nick Wareham
  • Kathryn E. Bradbury
  • Magdalena Stepien
  • Talita Duarte-Salles
  • Elio Riboli
  • Mazda Jenab
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • obesity, abdominal obesity, body composition, colorectal neoplasms, survival
Original languageEnglish
Pages (from-to)1949-1960
JournalInternational Journal of Cancer
Volume135
Issue number8
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Surgery Research Unit (013242220)