Prediagnostic immunoglobulin E levels and risk of chronic lymphocytic leukemia, other lymphomas and multiple myeloma-results of the European Prospective Investigation into Cancer and Nutrition.

Research output: Contribution to journalArticle

Abstract

Previous epidemiological studies suggest an inverse association between allergies, marked by elevated immunoglobulin (Ig) E levels, and non-Hodgkin lymphoma (NHL) risk. The evidence, however, is inconsistent and prospective data are sparse. We examined the association between prediagnostic total (low: <20; intermediate: 20-100; high >100 kU/l) and specific IgE (negative: <0.35; positive ≥0.35 kU/I) concentrations against inhalant antigens and lymphoma risk in a study nested within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 1021 incident cases and matched controls of NHL, multiple myeloma (MM) and Hodgkin lymphoma with a mean follow-up time of 7 years were investigated. Multivariate-adjusted odds ratios (ORs) with 95% confidence intervals (CI) were calculated by conditional logistic regression. Specific IgE was not associated with the risk of MM, B-cell NHL and B-cell NHL subtypes. In contrast, total IgE levels were inversely associated with the risk of MM [high level: OR = 0.40 (95% CI = 0.21-0.79)] and B-cell NHL [intermediate level: OR = 0.68 (95% CI = 0.53-0.88); high level: OR = 0.62 (95% CI = 0.44-0.86)], largely on the basis of a strong inverse association with chronic lymphocytic leukemia [CLL; intermediate level: OR = 0.49 (95% CI = 0.30-0.80); high level: OR = 0.13 (95% CI = 0.05-0.35)] risk. The inverse relationship for CLL remained significant for those diagnosed 5 years after baseline. The findings of this large prospective study demonstrated significantly lower prediagnostic total IgE levels among CLL and MM cases compared with matched controls. This corresponds to the clinical immunodeficiency state often observed in CLL patients prior to diagnosis. No support for an inverse association between prediagnostic levels of specific IgE and NHL risk was found.

Details

Authors
  • Alexandra Nieters
  • Anna Luczyńska
  • Susen Becker
  • Nikolaus Becker
  • Roel Vermeulen
  • Kim Overvad
  • Krasimira Aleksandrova
  • Heiner Boeing
  • Pagona Lagiou
  • Dimitrios Trichopoulos
  • Antonia Trichopoulou
  • Vittorio Krogh
  • Giovanna Masala
  • Salvatore Panico
  • Rosario Tumino
  • Carlotta Sacerdote
  • Bas Bueno-de-Mesquita
  • Suzanne M Jeurnink
  • Elisabete Weiderpass
  • Eva Ardanaz
  • Maria-Dolores Chirlaque
  • María-José Sánchez
  • Soledad Sánchez
  • Beatrice Melin
  • Florentin Späth
  • Sabina Rinaldi
  • Paul Brennan
  • Rachel S Kelly
  • Elio Riboli
  • Paolo Vineis
  • Rudolf Kaaks
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)2716-2722
JournalCarcinogenesis
Volume35
Issue number12
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes