Prediction of disease-related mutations affecting protein localization.

Research output: Contribution to journalArticle

Abstract

Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein is not transported to the correct intracellular compartment either the reaction performed or information carried by the protein does not reach the proper site, causing either inactivation of central reactions or misregulation of signalling cascades, or the mislocalized active protein has harmful effects by acting in the wrong place.

Details

Authors
External organisations
  • University of Tampere
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Genetics

Keywords

  • Computational Biology: methods, Genetic Predisposition to Disease: genetics, Intracellular Space: metabolism, Proteins: genetics, Proteins: metabolism
Original languageEnglish
Article number122
JournalBMC Genomics
Volume10
Publication statusPublished - 2009
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes