Pregnancy Rate and Outcome in Swedish Women With Turner Syndrome EDITORIAL COMMENT

Research output: Contribution to journalDebate/Note/Editorial

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Pregnancy Rate and Outcome in Swedish Women With Turner Syndrome EDITORIAL COMMENT. / Bryman, Inger; Sylven, Lisskulla; Berntorp, Kerstin; Innala, Eva; Bergstrom, Ingrid; Hanson, Charles; Oxholm, Marianne; Landin-Wilhelmsen, Kerstin.

In: Obstetrical and Gynecological Survey, Vol. 66, No. 12, 2011, p. 756-757.

Research output: Contribution to journalDebate/Note/Editorial

Harvard

Bryman, I, Sylven, L, Berntorp, K, Innala, E, Bergstrom, I, Hanson, C, Oxholm, M & Landin-Wilhelmsen, K 2011, 'Pregnancy Rate and Outcome in Swedish Women With Turner Syndrome EDITORIAL COMMENT', Obstetrical and Gynecological Survey, vol. 66, no. 12, pp. 756-757. https://doi.org/10.1097/OGX.0b013e318238897d

APA

Bryman, I., Sylven, L., Berntorp, K., Innala, E., Bergstrom, I., Hanson, C., Oxholm, M., & Landin-Wilhelmsen, K. (2011). Pregnancy Rate and Outcome in Swedish Women With Turner Syndrome EDITORIAL COMMENT. Obstetrical and Gynecological Survey, 66(12), 756-757. https://doi.org/10.1097/OGX.0b013e318238897d

CBE

MLA

Vancouver

Author

Bryman, Inger ; Sylven, Lisskulla ; Berntorp, Kerstin ; Innala, Eva ; Bergstrom, Ingrid ; Hanson, Charles ; Oxholm, Marianne ; Landin-Wilhelmsen, Kerstin. / Pregnancy Rate and Outcome in Swedish Women With Turner Syndrome EDITORIAL COMMENT. In: Obstetrical and Gynecological Survey. 2011 ; Vol. 66, No. 12. pp. 756-757.

RIS

TY - JOUR

T1 - Pregnancy Rate and Outcome in Swedish Women With Turner Syndrome EDITORIAL COMMENT

AU - Bryman, Inger

AU - Sylven, Lisskulla

AU - Berntorp, Kerstin

AU - Innala, Eva

AU - Bergstrom, Ingrid

AU - Hanson, Charles

AU - Oxholm, Marianne

AU - Landin-Wilhelmsen, Kerstin

PY - 2011

Y1 - 2011

N2 - The rate of spontaneous pregnancies in women with Turner syndrome (TS) is low (2% to 5%). Oocyte donation is an option for these women and enables many to become pregnant. Some investigators question the use of pregnancy induction in TS because of the high risk for aortic dissection or other serious cardiac events. A cardiac evaluation is recommended before pregnancy is planned in TS. Among patients with TS who use their own oocytes to become pregnant, 45% suffered a miscarriage. The aim of this study was to assess pregnancy rate and outcome in a population of Swedish women with spontaneous pregnancies or who were induced using donated oocytes. Cytogenetic karyotype also was examined; mosaicism was defined as the presence of more than 5% 46, XX cells. The study subjects were 482 women with TS who had participated in a voluntary screening program conducted at Swedish Turner Centers. Among the 482 women with TS, 57 (12%) had pregnancies, including spontaneous pregnancies. The live-born rate was 67 of 124 (54%). The patient's own oocytes were used in 27 (47%) of the pregnancies and oocyte donation in 30 (53%) of pregnancies. Spontaneous pregnancies occurred in 23 of 57 women (40%) with TS. Most pregnancies using the patient's own oocytes occurred in those with 45, X/46, XX mosaic karyotype. The miscarriage rate was 26% after oocyte donation and 45% with the use of the patient's own oocytes. Five liveborns (7%) had birth defects or a serious illness; 4 of these were born after spontaneous pregnancies. Only 1 live-born had coarctation of the aorta.

AB - The rate of spontaneous pregnancies in women with Turner syndrome (TS) is low (2% to 5%). Oocyte donation is an option for these women and enables many to become pregnant. Some investigators question the use of pregnancy induction in TS because of the high risk for aortic dissection or other serious cardiac events. A cardiac evaluation is recommended before pregnancy is planned in TS. Among patients with TS who use their own oocytes to become pregnant, 45% suffered a miscarriage. The aim of this study was to assess pregnancy rate and outcome in a population of Swedish women with spontaneous pregnancies or who were induced using donated oocytes. Cytogenetic karyotype also was examined; mosaicism was defined as the presence of more than 5% 46, XX cells. The study subjects were 482 women with TS who had participated in a voluntary screening program conducted at Swedish Turner Centers. Among the 482 women with TS, 57 (12%) had pregnancies, including spontaneous pregnancies. The live-born rate was 67 of 124 (54%). The patient's own oocytes were used in 27 (47%) of the pregnancies and oocyte donation in 30 (53%) of pregnancies. Spontaneous pregnancies occurred in 23 of 57 women (40%) with TS. Most pregnancies using the patient's own oocytes occurred in those with 45, X/46, XX mosaic karyotype. The miscarriage rate was 26% after oocyte donation and 45% with the use of the patient's own oocytes. Five liveborns (7%) had birth defects or a serious illness; 4 of these were born after spontaneous pregnancies. Only 1 live-born had coarctation of the aorta.

U2 - 10.1097/OGX.0b013e318238897d

DO - 10.1097/OGX.0b013e318238897d

M3 - Debate/Note/Editorial

VL - 66

SP - 756

EP - 757

JO - Obstetrical and Gynecological Survey

JF - Obstetrical and Gynecological Survey

SN - 0029-7828

IS - 12

ER -