Prehospital administration of P2Y12 inhibitors and early coronary reperfusion in primary PCI: an observational comparative study

Research output: Contribution to journalArticle

Abstract

The newer oral P2Y12 inhibitors prasugrel and ticagrelor have been reported to be more potent and faster-acting antiplatelet agents than clopidogrel. This study aimed to investigate whether prehospital loading with prasugrel or ticagrelor improves early coronary reperfusion as compared to prehospital loading with clopidogrel in a real-world ST-elevation myocardial infarction (STEMI) setting. Over a 70-month period, 3497 patients with on-going STEMI of less than 6 hours and without cardiac arrest or cardiogenic shock underwent primary percutaneous coronary intervention (PPCI) at our centre. The primary endpoint of this study was the proportion of patients who did not meet the criteria for TIMI (Thrombolysis In Myocardial Infarction) flow grade 3 in the infarct-related artery at initial angiography before PPCI. Prehospital loading with prasugrel (n = 883) or ticagrelor (n = 491) did not significantly improve coronary reperfusion as compared to prehospital loading with clopidogrel (n = 1,532) - a TIMI-flow 3 at initial angiography was absent in 71.7 %, 69.0 % and 71.5 % of patients, respectively. Major adverse cardiac event (MACE) rates were low at 30 days (3.4 % to 4.0 %) and did not significantly differ between the different P2Y12 inhibitor regimens. In conclusion, this large observational, non-randomised study is the first to show that prehospital loading with the newer P2Y12 inhibitors does not improve early coronary reperfusion as compared to prehospital loading with clopidogrel in a PPCI cohort excluding cardiac arrest and cardiogenic shock.

Details

Authors
  • Ole De Backer
  • Hanna Ratcovich
  • Luigi Biasco
  • Frants Pedersen
  • Steffen Helqvist
  • Kari Saunamäki
  • Hans-Henrik Tilsted
  • Peter Clemmensen
  • Goran Olivecrona
  • Henning Kelbaek
  • Erik Jørgensen
  • Thomas Engstrøm
  • Lene Holmvang
External organisations
  • Juliane Marie Centre, Rigshospitalet
  • Copenhagen University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • Adenosine/administration & dosage, Aged, Clopidogrel, Coronary Angiography, Coronary Circulation/drug effects, Drug Administration Schedule, Emergency Medical Services, Female, Humans, Male, Middle Aged, Myocardial Infarction/blood, Percutaneous Coronary Intervention/adverse effects, Platelet Aggregation Inhibitors/administration & dosage, Prasugrel Hydrochloride/administration & dosage, Purinergic P2Y Receptor Antagonists/administration & dosage, Ticagrelor, Ticlopidine/administration & dosage, Time Factors, Treatment Outcome
Original languageEnglish
Pages (from-to)623-31
JournalThrombosis and Haemostasis
Volume114
Issue number3
Publication statusPublished - 2015 Aug 31
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes