Pre-treatment dosimetry for interstitial photodynamic therapy

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

A genetic algorithm for optimal placement of optical fibers in arbitrary geometries for interstitial photodynamic therapy has been developed. Based on calculated fiber positions, the diffuse light distribution is simulated by solving the diffusion equation by means of the finite element method and the treatment time is calculated. Utilizing an instrument for interstitial photodynamic therapy that is capable of both delivering the therapeutic irradiation and measuring parameters of relevance to treatment monitoring, knowledge has been gained on temporal variations of tissue light absorption, sensitizer photobleaching and tissue oxygenation status. We speculate on how variations in these three parameters can be implemented in a crude pre-treatment dosimetry model for photodynamic therapy

Details

Authors
  • Ann Johansson
  • J Hjelm
  • A Eriksson
  • Stefan Andersson-Engels
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Atom and Molecular Physics and Optics

Keywords

  • tissue oxygenation, sensitizer photobleaching, tissue light absorption, finite element method, genetic algorithm, dosimetry, interstitial photodynamic therapy
Original languageEnglish
Title of host publicationProceedings of the SPIE - The International Society for Optical Engineering
PublisherSPIE
Pages58630S-1-58630S-11
Volume5863
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes
EventTherapeutic Laser Applications and Laser-Tissue Interactions II - Munich, Germany
Duration: 0001 Jan 2 → …

Publication series

Name
Number1
Volume5863
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceTherapeutic Laser Applications and Laser-Tissue Interactions II
Country/TerritoryGermany
CityMunich
Period0001/01/02 → …