Prevalence of Helicobacter pylori vacA and cagA genotypes in Ethiopian dyspeptic patients

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Abstract

A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the s1/m1 genotype was the most common in gastric biopsy samples (48%). The vacA and cagA positive H. pylori strains were detected to a higher degree in patients with chronic active gastritis (71%) than patients with other histopathological findings (29%) (P < 0.05).

Details

Authors
  • Daniel Asrat
  • Ingrid Nilsson
  • Yohannes Mengistu
  • Endale Kassa
  • Senait Ashenafi
  • Kiros Ayenew
  • Torkel Wadström
  • Waleed Abu Al-Soud
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area
Original languageEnglish
Pages (from-to)2682-2684
JournalJournal of Clinical Microbiology
Volume42
Issue number6
Publication statusPublished - 2004
Publication categoryResearch
Peer-reviewedYes

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