Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

Research output: Contribution to journalArticle

Abstract

Introduction: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. Methods: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. Results: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. Discussion: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures. © 2019

Details

Authors
External organisations
  • King's College London
  • Steno Diabetes Center Copenhagen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Alzheimer's disease, Amyloid, Biomarkers, Brain volume measurements, Cognitive function measurements, CSF, Dementia, EMIF-AD, Metabolomics, Tau, amide, amino acid, amyloid beta protein, aspartic acid, biological marker, cholinesterase inhibitor, fatty acid, glutamic acid, oleamide, tau protein, aged, Alzheimer disease, Article, brain function, brain size, cognition, cohort analysis, controlled study, dementia, disease association, female, hippocampus, human, logistic regression analysis, major clinical study, male, memory, metabolomics, mild cognitive impairment, Mini Mental State Examination, neuropsychological test, nuclear magnetic resonance imaging, plasma, predictive value, priority journal, protein cerebrospinal fluid level
Original languageEnglish
Pages (from-to)817-827
Number of pages11
JournalAlzheimer's and Dementia
Volume15
Issue number6
Publication statusPublished - 2019 Jun
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes