Progenitor cells in the postnatal central nervous system, characterization and genetic manipulation

Research output: ThesisDoctoral Thesis (compilation)

Abstract

New neurons are only generated in two places of the postnatal brain; the subventricular zone (SVZ) and hippocampus. The SVZ-derived cells specifically migrate to the olfactory bulb where they give rise to new interneurons. We have genetically manipulated the postnatal SVZ progenitor cells with the aim to direct them to a neuronal fate in the striatum. Our result showed that ectopic expression of the transcription factors Islet1 and Neurogenin2 directed the SVZ cells progeny to a new fate in the striatum and external capsule. Once removed to the culture dish they expressed the neuronal marker ?-III-tubulin. Thus, showing that ectopic expression of Islet1 and Neurogenin2 in the postnatal SVZ progenitor cells promote striatal recruitment for their progeny, which have potential to differentiate into neurons.

Details

Authors
  • Nina Rogelius
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Medicin (människa och djur), Medicine (human and vertebrates), subventricular zone, Islet1, Neurogenin2, respecification, in vivo., transcription factors, neurogenesis, Progenitor cells, stem cells
Original languageEnglish
QualificationDoctor
Awarding Institution
Supervisors/Assistant supervisor
Award date2007 Jun 9
Publisher
  • Department of Experimental Medical Science, Lund Univeristy
Print ISBNs978-91-85559-84-8
Publication statusPublished - 2007
Publication categoryResearch

Bibliographic note

Defence details Date: 2007-06-09 Time: 09:00 Place: Segerfalksalen, Wallenberg Neurocentrum, Lund. External reviewer(s) Name: Eriksson, Peter Title: Professor Affiliation: Sektionen för klinisk neurovetenskap och rehabilitering ---

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