Prognostic Significance of Stromal Platelet-Derived Growth Factor beta-Receptor Expression in Human Breast Cancer

Research output: Contribution to journalArticle

Abstract

This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations between PDGF beta-receptor status and clinicopathological characteristics in breast cancer. PDGF receptor expression was determined by immunohistochemistry on tumor tissue microarrays. Breast tumor data were combined with prognostic factors and related to outcome endpoints. PDGF alpha- and beta-receptors were independently expressed, at variable frequencies, in the tumor stroma of all tested tumor types. There was a significant association between PDGF beta-receptor expression on fibroblasts and perivascular cells in individual colon and prostate tumors. In breast cancer, high stromal PDGF beta-receptor expression was significantly associated with high histopathological grade, estrogen receptor negativity, and high HER2 expression. High stromal PDGF beta-receptor expression was correlated with significantly shorter recurrence-free and breast cancer-specific survival. The prognostic significance of stromal PDGF beta-receptor expression was particularly prominent in tumors from premenopausal women. Stromal PDGF alpha- and beta-receptor expression is a common, but variable and independent, property of solid tumors. in breast cancer, stromal PDGF beta-receptor expression significantly correlates with less favorable clinicopatho-logical parameters and shorter survival. These findings highlight the prognostic significance of stromal markers and should be considered in ongoing clinical development of PDGF receptor inhibitors. (Am J Pathol 2009, 175.334-341; DOI: 10.2353/ajpath.2009.081030)

Details

Authors
  • Janna Paulsson
  • Tobias Sjoblom
  • Patrick Micke
  • Fredrik Ponten
  • Goran Landberg
  • Carl-Henrik Heldin
  • Jonas Bergh
  • Donal J. Brennan
  • Karin Jirström
  • Arne Ostman
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)334-341
JournalAmerican Journal of Pathology
Volume175
Issue number1
Publication statusPublished - 2009
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology (Malmö) (013031000), Pathology, (Lund) (013030000)