Progress update from the hippocampal subfields group

Research output: Contribution to journalArticle


Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide. © 2019 The Authors


  • Rosanna K. Olsen
  • David Berron
  • Laura E.M. Wisse
  • Hippocampal Subfields Group
External organisations
  • Baycrest Health Sciences
  • University of Toronto
  • German Center for Neurodegenerative Diseases (DZNE), Bonn
  • University of Pennsylvania
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology


  • Cytoarchitecture, ex vivo, Hippocampus, Histology, Human, Neuroanatomy, Neuroimaging, Structural imaging, Volumetry
Original languageEnglish
Pages (from-to)439-449
Number of pages11
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Publication statusPublished - 2019
Publication categoryResearch