Progressive decline in renal function induces a gradual decrease in total hemoglobin and exercise capacity

Research output: Contribution to journalArticle


We examined 58 patients (38 men, 20 women; mean age: 45 ± 12 years, body mass index: 24 ± 4 kg/m2) with a glomerular filtration rate (GFR) ranging from 3 to 32 ml/min, in order to determine the effects of a progressive decline in renal function on total hemoglobin (THb) and exercise capacity. The THb ranged from 185 to 759 g and the hemoglobin concentration ranged from 66 to 151 g/l. Maximal exercise capacity ranged from 50 to 260 W (40-143% of the expected norm). Nearly all the patients interrupted their exercise tests due to general fatigue, leg tiredness or a combination of these factors. There was a significant partial correlation between THb and GFR after sex and age had been accounted for (r = 0.39; p <0.005). Maximal exercise capacity and THb showed a significant partial correlation after sex, age and GFR had been accounted for (r = 0.27; p


  • N. Clyne
  • T. Jogestrand
  • L. E. Lins
  • S. K. Pehrsson
External organisations
  • Karolinska University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology


  • Chronic renal failure, Exercise capacity, Glomerular filtration rate, Hemoglobin total
Original languageEnglish
Pages (from-to)322-326
Number of pages5
Issue number3
Publication statusPublished - 1994
Publication categoryResearch
Externally publishedYes